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| Item Type: | Book Section |
|---|---|
| Title: | Neurons and other excitable cells |
| Creators Name: | Dupont, G., Falcke, M., Kirk, V. and Sneyd, J. |
| Abstract: | Calcium plays a major role in every neuron. Not only does it play a part in controlling the membrane potential, but it is also a crucial ingredient of both the pre-synaptic and post-synaptic terminals. At the pre-synaptic terminal the secretion of neurotransmitter is controlled by Ca2+, as is short-term plasticity , while in the post-synaptic terminal Ca(2+) is both necessary and sufficient for long-term synaptic plasticity, i.e., long-term depression, long-term potentiation, and spike-timing-dependent plasticity. In neuroendocrine cells from the hypothalamus and pituitary, as well as in the endocrine pancreas, Ca(2+) controls the membrane potential, the shape of the bursts of electrical spiking, and the secretion of hormones. In photoreceptors and olfactory receptors , Ca(2+) is at the centre of the biochemical networks that control adaptation to a maintained stimulus, while in interstitial cells of Cajal Ca(2+) controls the membrane potential in ways that we do not yet fully understand. There are many other examples of the importance of Ca(2+) in neurons and excitable cells. |
| Keywords: | GnRH Neuron, Fast Subsystem, Geometric Singular Perturbation Theory, Interburst Interval, Pancreatic Alpha Cell |
| Series Name: | Interdisciplinary Applied Mathematics |
| Title of Book: | Models of Calcium Signalling |
| ISSN: | 0939-6047 |
| ISBN: | 978-3-319-29645-6 |
| Publisher: | Springer |
| Volume: | 43 |
| Page Range: | 337-385 |
| Date: | 2016 |
| Official Publication: | https://doi.org/10.1007/978-3-319-29647-0_8 |
| Related to: |
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