SARS-CoV-2 effects on the renin-angiotensin-aldosterone system, therapeutic implications

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Item Type:	Editorial
Title:	SARS-CoV-2 effects on the renin-angiotensin-aldosterone system, therapeutic implications
Creators Name:	Ye, Q., Lai, E.Y., Luft, F.C., Persson, P.B. and Mao, J.
Abstract:	Angiotensin converting enzyme-2 (ACE-2) is the cell-surface receptor enabling viral uptake of corona virus 2019 (SARS-CoV-2), thus ACE-2 is a first step towards COVID-19 disease. ACE-2 is a metalloenzyme located primarily on the apical surface, and serves as the entry point also for other coronaviruses, including HCoV-NL63 and SARS-CoV. Throughout evolution, ACE-2 precedes renin, suggesting that ACE-2's role changed over time.
Keywords:	Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, COVID-19, Cardiovascular Disease, Renin-Angiotensin System, SARS-CoV-2, Animals, Mice
Source:	Acta Physiologica
ISSN:	1748-1708
Publisher:	Wiley
Volume:	231
Number:	4
Page Range:	e13608
Date:	April 2021
Official Publication:	https://doi.org/10.1111/apha.13608
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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