Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

RNA sequencing of human peripheral blood cells indicates upregulation of immune-related genes in Huntington's disease

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[thumbnail of Supplementary Material] Other (Supplementary Material)
5MB

Item Type:Article
Title:RNA sequencing of human peripheral blood cells indicates upregulation of immune-related genes in Huntington's disease
Creators Name:Andrade-Navarro, M.A., Mühlenberg, K., Spruth, E.J., Mah, N., González-López, A., Andreani, T., Russ, J., Huska, M.R., Muro, E.M., Fontaine, J.F., Amstislavskiy, V., Soldatov, A., Nietfeld, W., Wanker, E.E. and Priller, J.
Abstract:Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the Huntingtin gene. As disease-modifying therapies for HD are being developed, peripheral blood cells may be used to indicate disease progression and to monitor treatment response. In order to investigate whether gene expression changes can be found in the blood of individuals with HD that distinguish them from healthy controls, we performed transcriptome analysis by next-generation sequencing (RNA-seq). We detected a gene expression signature consistent with dysregulation of immune-related functions and inflammatory response in peripheral blood from HD cases vs. controls, including induction of the interferon response genes, IFITM3, IFI6 and IRF7. Our results suggest that it is possible to detect gene expression changes in blood samples from individuals with HD, which may reflect the immune pathology associated with the disease.
Keywords:RNA-Seq, Differential Gene Expression, Huntington's Disease, Disease Markers, Inflammation
Source:Frontiers in Neurology
ISSN:1664-2295
Publisher:Frontiers Media SA
Volume:11
Page Range:573560
Date:27 November 2020
Official Publication:https://doi.org/10.3389/fneur.2020.573560
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library