Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

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Item Type:	Letter
Title:	Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
Creators Name:	Michalick, L., Weidenfeld, S., Grimmer, B., Fatykhova, D., Solymosi, P.D., Behrens, F., Dohmen, M., Brack, M.C., Schulz, S., Thomasch, E., Simmons, S., Müller-Redetzky, H., Suttorp, N., Kurth, F., Neudecker, J., Toennies, M., Bauer, T.T., Eggeling, S., Corman, V.M., Hocke, A.C., Witzenrath, M., Hippenstiel, S. and Kuebler, W.M.
Abstract:	Plasma of COVID-19 patients induces pulmonary microvascular barrier failure which increases with disease severity. Here, we report a versatile high-throughput screening platform to test for involved plasma mediators and the therapeutic potential of barrier stabilising compounds.
Keywords:	Actins, CD Antigens, COVID-19, Cadherins, Capillary Permeability, Case-Control Studies, Electric Impedance, Endothelial Cells, Endothelium, Hospitalization, Lung, Microvessels, Occludin, Plasma, SARS-CoV-2, Severity of Illness Index
Source:	European Respiratory Journal
ISSN:	0903-1936
Publisher:	European Respiratory Society
Volume:	57
Number:	3
Page Range:	2002384
Date:	11 March 2021
Official Publication:	https://doi.org/10.1183/13993003.02384-2020
PubMed:	View item in PubMed

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