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Sinusoidal obstruction syndrome following myeloablative therapy and tranexamic acid treatment for hemorrhage in two patients with neuroblastoma

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Item Type:Article
Title:Sinusoidal obstruction syndrome following myeloablative therapy and tranexamic acid treatment for hemorrhage in two patients with neuroblastoma
Creators Name:Zirngibl, F., Flemmig, C., Lang, P., Künkele, A., Eggert, A., Schulte, J.H. and Deubzer, H.E.
Abstract:Adverse thromboembolic events following administration of the anti-fibrinolytic agent tranexamic acid (TA), used to prevent/treat excessive blood loss, are rare. We present the clinical course of two young patients (22 and 56 months) receiving busulfan/melphalan (Bu/Mel) high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HSCT) to treat high-risk neuroblastoma, who developed hepatic sinusoidal obstruction syndrome (SOS) within 48 h after systemic TA treatment for a hemodynamically relevant hemorrhage. Defibrotide treatment resolved hepatic SOS, but the short time between TA administration and SOS onset suggests a causal association.
Keywords:Pediatric Hematopoietic Stem Cell Transplantation, Embryonal Tumor, Transplant-Related Complication, Fibrinolysis Inhibitor, Thrombotic Event
Source:Children
ISSN:2227-9067
Publisher:MDPI
Volume:7
Number:11
Page Range:198
Date:November 2020
Official Publication:https://doi.org/10.3390/children7110198
PubMed:View item in PubMed

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