Systems biology approach to study cancer metabolism

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Item Type:	Book Section
Title:	Systems biology approach to study cancer metabolism
Creators Name:	Kempa, S. and Royla, N.
Abstract:	Transformation of cells into tumor cells is directly linked to a reprogramming of metabolism. Thus genomic or epigenomic alterations translate into adaptations of the biochemical phenotype of a cell. We are just at the beginning of understanding the mechanisms behind the metabolic reprogramming of metabolism as it includes all regulatory levels; (epi-) genomic, (post) transcriptional, (post) translational, and allosteric. In order to decode the regulatory mechanisms during metabolic reprogramming a systems view is needed that allows to follow the flow of information from the genome to metabolism.
Keywords:	Gene Regulation, Metabolic Feedback, Metabolomics, Stable Isotope Resolved Metabolomics (pSIRM), Systems Biology
Source:	Encyclopedia of Cancer
Title of Book:	Encyclopedia of Cancer
ISBN:	978-0-12-812485-7
Publisher:	Elsevier / Academic Press
Volume:	3
Page Range:	426-428
Date:	2019
Official Publication:	https://doi.org/10.1016/B978-0-12-801238-3.65125-5

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