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Microscopy with undetected photons in the mid-infrared

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Item Type:Article
Title:Microscopy with undetected photons in the mid-infrared
Creators Name:Kviatkovsky, I., Chrzanowski, H.M., Avery, E.G., Bartolomaeus, H. and Ramelow, S.
Abstract:Owing to its capacity for unique (bio)-chemical specificity, microscopy with mid-infrared (IR) illumination holds tremendous promise for a wide range of biomedical and industrial applications. The primary limitation, however, remains detection, with current mid-IR detection technology often marrying inferior technical capabilities with prohibitive costs. Here, we experimentally show how nonlinear interferometry with entangled light can provide a powerful tool for mid-IR microscopy while only requiring near-IR detection with a silicon-based camera. In this proof-of-principle implementation, we demonstrate widefield imaging over a broad wavelength range covering 3.4 to 4.3 μm and demonstrate a spatial resolution of 35 μm for images containing 650 resolved elements. Moreover, we demonstrate that our technique is suitable for acquiring microscopic images of biological tissue samples in the mid-IR. These results form a fresh perspective for potential relevance of quantum imaging techniques in the life sciences.
Keywords:Animals, Mice
Source:Science Advances
ISSN:2375-2548
Publisher:American Association for the Advancement of Science
Volume:6
Number:42
Page Range:eabd0264
Date:14 October 2020
Official Publication:https://doi.org/10.1126/sciadv.abd0264
PubMed:View item in PubMed

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