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A palladium-catalyzed domino reaction to access 3-amino-2H-indazoles from hydrazines and 2-halobenzonitriles

Item Type:Article
Title:A palladium-catalyzed domino reaction to access 3-amino-2H-indazoles from hydrazines and 2-halobenzonitriles
Creators Name:Alsalim, R., Lindemann, P., López-Alberca, M.P., Miksche, S., Czechtizky, W., Halland, N. and Nazaré, M.
Abstract:The development of a novel selective synthesis of 3-amino-2H-indazoles from readily available 2-halobenzonitriles is presented. The reaction proceeds through a domino reaction sequence, consisting of a regioselective palladium-catalyzed coupling of monosubstituted hydrazines with 2-halobenzonitriles, followed by an intramolecular hydroamination through a 5-exo-dig cyclization and subsequent isomerization to directly afford a wide variety of substituted 2H-indazole analogues in good to excellent yields.
Source:Organic Letters
ISSN:1523-7060
Publisher:American Chemical Society
Volume:22
Number:18
Page Range:7393-7396
Date:18 September 2020
Official Publication:https://doi.org/10.1021/acs.orglett.0c02766
PubMed:View item in PubMed

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