![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
456kB |
| Item Type: | Review |
|---|---|
| Title: | Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection |
| Creators Name: | Wizenty, J., Tacke, F. and Sigal, M. |
| Abstract: | Helicobacter pylori (H. pylori) are gram-negative bacteria that are able to colonize and persist in the stomach. Gastric cancer is tightly linked to chronic infection with this bacterium. Research over the last decades has illuminated the molecular interactions between H. pylori and host cells. It is now well established that H. pylori have multiple sophisticated means to adhere to epithelial cells and to manipulate their behavior. This interaction with the epithelium can lead to altered cell signaling, DNA damage and aberrant epithelial immunity. H. pylori are known to colonize the mucus layer of the stomach and surface epithelial cells. In addition, it has recently become clear that they can also penetrate the glands and directly interact with specialized epithelial cells deep in the glands. Understanding the biogeography of infection is important because gastric epithelial glands are composed of various types of short-lived differentiated cells that are constantly regenerated by a limited pool of long-lived stem cells located in base of gastric glands. Recent advances in gastric stem cell research not only led to identification of stem cell populations using specific markers but has also uncovered specific regulatory pathways and principles that govern gastric stem cell behavior and regeneration. Particularly, the stem cell state is largely dependent on signals from the niche cells that surround the stem cell compartment. The subpopulation of H. pylori that colonizes in the stem cell compartment triggers specific inflammatory responses and drives epithelial pathology. Colonization of gastric glands induces responses of the stem cell niche, simultaneously enhancing the cell turnover kinetics and driving the formation of antimicrobial cells in the gland base. These data reveal the high plasticity of the epithelium and its ability to adapt to the environment, which is necessary to regenerate and counterbalance infection, but simultaneously lays the grounds for development of gastric pathology and carcinogenesis. |
| Keywords: | Antimicrobial Defense, Helicobacter pylori (H. pylori), Plasticity, Stem Cells, Stomach, Animals, Mice |
| Source: | Annals of Translational Medicine |
| ISSN: | 2305-5839 |
| Publisher: | AME Publishing Company |
| Volume: | 8 |
| Number: | 8 |
| Page Range: | 568 |
| Date: | April 2020 |
| Additional Information: | Copyright©Annals of Translational Medicine. All rights reserved. |
| Official Publication: | https://doi.org/10.21037/atm.2020.02.178 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
