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| Item Type: | Article |
|---|---|
| Title: | The Chimera-type galectin-3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus |
| Creators: |
Freitag, N.  ORCID: https://orcid.org/0000-0001-5972-1863, Tirado-González, I., Barrientos, G., Cohen, M., Daher, S. ORCID: https://orcid.org/0000-0001-5312-7804, Goldman-Wohl, D., Mincheva-Nilsson, L. ORCID: https://orcid.org/0000-0001-6301-7940, John, C., Jeschke, U. ORCID: https://orcid.org/0000-0003-2623-3235 and Blois, S.M. ORCID: https://orcid.org/0000-0002-0434-2660
|
| Abstract: | PROBLEM: From conception, a delicate regulation of galectins, a family of carbohydrate-binding proteins, is established to ensure maternal immune tolerance in pregnancy. Though galectin-3 (gal-3), the only chimera type galectin, is abundantly expressed at the feto-maternal interface; the physiological role of this lectin during pregnancy remains to be fully elucidated and requires further investigation. METHOD OF STUDY: In this study, we analyzed serum gal-3 levels during the course of healthy gestation. Trophoblast functions were evaluated upon gal-3 exogenous stimulation using trophoblastic cell lines (e.g. HIPEC65, SGHPL-4 and BeWo cells). Finally, we investigated variations in peripheral gal-3 levels associated with the development of spontaneous abortion and gestational diabetes mellitus (GDM). RESULTS: Gal-3 circulating levels increased as normal pregnancy progressed. In vitro experiments showed that exogenous gal-3 positively regulated trophoblast functions inducing invasion, tube formation and fusion. Compared with normal pregnant women, circulating gal-3 levels were significantly decreased in patients who developed GDM. CONCLUSION: Our results reveal a physiological role for gal-3 during pregnancy, promoting proper trophoblast functions associated with healthy gestation. GDM is associated with a failure to increase circulating gal-3 levels late in gestation. Thus, dysregulation of gal-3 may indicate a contribution of the chimera-type lectin to this adverse pregnancy outcome. |
| Keywords: | gal-3, Placenta, Trophoblast, Pathological Pregnancy |
| Source: | American Journal of Reproductive Immunology |
| ISSN: | 1046-7408 |
| Publisher: | Wiley |
| Volume: | 84 |
| Number: | 6 |
| Page Range: | e13311 |
| Date: | December 2020 |
| Official Publication: | https://doi.org/10.1111/aji.13311 |
| PubMed: | View item in PubMed |
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