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| Item Type: | Article |
|---|---|
| Title: | SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes |
| Creators Name: | Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K.B., Yoshida, M. and Barnes, J.L. |
| Abstract: | We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. |
| Source: | Nature Medicine |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Volume: | 26 |
| Number: | 5 |
| Page Range: | 681-687 |
| Date: | May 2020 |
| Additional Information: | Norbert Hübner is a member of the HCA Lung Biological Network. Copyright © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. |
| Official Publication: | https://doi.org/10.1038/s41591-020-0868-6 |
| External Fulltext: | View full text on PubMed Central |
| PubMed: | View item in PubMed |
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