Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

Nitzan, N.; McKenzie, S.; Beed, P.; English, D.F.; Oldani, S.; Tukker, J.J.; Buzsáki, G.; Schmitz, D.

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

Tools

Preview	PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 6MB
	Other (Supplementary Information) 153MB

Item Type:	Article
Title:	Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway
Creators Name:	Nitzan, N., McKenzie, S., Beed, P., English, D.F., Oldani, S., Tukker, J.J., Buzsáki, G. and Schmitz, D.
Abstract:	Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.
Keywords:	Brain Waves, Hippocampal CA1 Region, Hippocampus, Neocortex, Neural Pathways, Neurons, Synaptic Transmission, Transgenic Mice, Vesicular Glutamate Transport Protein 2, Wakefulness, Animals, Mice
Source:	Nature Communications
ISSN:	2041-1723
Publisher:	Nature Publishing Group
Volume:	11
Number:	1
Page Range:	1947
Date:	23 April 2020
Additional Information:	Erratum in: Nat Commun 11(1): 3472.
Official Publication:	https://doi.org/10.1038/s41467-020-15787-8
PubMed:	View item in PubMed

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year