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| Item Type: | Article |
|---|---|
| Title: | The sensory coding of warm perception |
| Creators Name: | Paricio-Montesinos, R., Schwaller, F., Udhayachandran, A., Rau, F., Walcher, J., Evangelista, R., Vriens, J., Voets, T., Poulet, J.F.A. and Lewin, G.R. |
| Abstract: | Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1°C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other. In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:trpa1:trpm3(-/-) triple-mutant mice that cannot sense noxious heat detected skin warming, albeit with reduced sensitivity. In contrast, loss or local pharmacological silencing of the cool-driven TRPM8 channel abolished the ability to detect warm. Our data are not reconcilable with a labeled line model for warm perception, with receptors firing only in response to warm stimuli, but instead support a conserved dual sensory model to unambiguously detect skin warming in vertebrates. |
| Keywords: | Perception, Sensory Coding, Warm, Thermal Transduction, Nociception, Polymodal, C-Fiber, TRP Channels, Animals, Mice |
| Source: | Neuron |
| ISSN: | 0896-6273 |
| Publisher: | Cell Press |
| Volume: | 106 |
| Number: | 5 |
| Page Range: | 830-841 |
| Date: | 3 June 2020 |
| Official Publication: | https://doi.org/10.1016/j.neuron.2020.02.035 |
| PubMed: | View item in PubMed |
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