Novel strategy for the preparation of 3-perfluoroalkylated-2 H-indazole derivatives

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Item Type:	Article
Title:	Novel strategy for the preparation of 3-perfluoroalkylated-2 H-indazole derivatives
Creators Name:	Bel Abed, H., Weißing, N., Schoene, J., Paulus, J., Sewald, N. and Nazaré, M.
Abstract:	A simple and novel methodology for the synthesis of 3-perfluoroalkylated-2H-indazole derivatives has been elaborated. The perfluoroalkylation of readily available 2-nitrobenzaldimines bearing electron donating groups was performed using the Ruppert-Prakash reagent and its analogues to afford α-difluoromethylated, α-trifluoromethylated and α-pentafluoroethylated benzylamines. A final reductive cyclization mediated by SnCl(2)·2H(2)O led to 2H-indazoles containing perfluoroalkyl groups via the generation of a new NN bond in moderate to good yields.
Keywords:	2H-Indazole, Perfluoroalkylation, N-N Bond Formation, Ruppert-Prakash Reagent, Reductive Cyclization
Source:	Tetrahedron Letters
ISSN:	0040-4039
Publisher:	Elsevier
Volume:	59
Number:	19
Page Range:	1813-1815
Date:	9 May 2018
Official Publication:	https://doi.org/10.1016/j.tetlet.2018.03.051

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