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| Item Type: | Article |
|---|---|
| Title: | Nervous system regionalization entails axial allocation before neural differentiation |
| Creators Name: | Metzis, V., Steinhauser, S., Pakanavicius, E., Gouti, M., Stamataki, D., Ivanovitch, K., Watson, T., Rayon, T., Mousavy Gharavy, S.N., Lovell-Badge, R., Luscombe, N.M. and Briscoe, J. |
| Abstract: | Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity; caudalizing signals then convert a proportion to posterior fates (spinal cord). To test this model, we used chromatin accessibility to define how cells adopt region-specific neural fates. Together with genetic and biochemical perturbations, this identified a developmental time window in which genome-wide chromatin-remodeling events preconfigure epiblast cells for neural induction. Contrary to the established model, this revealed that cells commit to a regional identity before acquiring neural identity. This "primary regionalization" allocates cells to anterior or posterior regions of the nervous system, explaining how cranial and spinal neurons are generated at appropriate axial positions. These findings prompt a revision to models of neural induction and support the proposed dual evolutionary origin of the vertebrate CNS. |
| Keywords: | Neural Induction, ATAC-seq, CDX, Embryonic Development, Chromatin, Spinal Cord, WNT Signaling, Stem Cells and Development, Computational Genomics, Gene Regulation, Animals, Mice |
| Source: | Cell |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Volume: | 175 |
| Number: | 4 |
| Page Range: | 1105-1118 |
| Date: | 1 November 2018 |
| Official Publication: | https://doi.org/10.1016/j.cell.2018.09.040 |
| PubMed: | View item in PubMed |
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