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| Item Type: | Book Section |
|---|---|
| Title: | Deciphering the universe of RNA structures and trans RNA-RNA interactions of transcriptomes in vivo: from experimental protocols to computational analyses |
| Creators Name: | Stefanov, S.R. and Meyer, I.M. |
| Abstract: | The last few years have seen an explosion of experimental and computational methods for investigating RNA structures of entire transcriptomes in vivo. Very recent experimental protocols now also allow trans RNA–RNA interactions to be probed in a transcriptome-wide manner. All of the experimental strategies require comprehensive computational pipelines for analysing the raw data and converting it back into actual RNA structure features or trans RNA–RNA interactions. The overall performance of these methods thus strongly depends on the experimental and the computational protocols employed. In order to get the best out of both worlds, both aspects need to be optimised simultaneously. This review introduced the methods and proposes ideas how they could be further improved. |
| Keywords: | RNA Secondary Structures, Trans RNA-RNA Interactions, RNA Structure Prediction, RNA-RNA Interaction Prediction, Transcriptomes, In Vivo RNA Structure Probing, In Vivo Probing of Trans RNA-RNA Interaction, RNA Structurome, RNA Interactome |
| Series Name: | RNA Technologies |
| Title of Book: | Systems Biology |
| ISSN: | 2197-9731 |
| ISBN: | 978-3-319-92966-8 |
| Publisher: | Springer |
| Page Range: | 173-216 |
| Date: | 2018 |
| Official Publication: | https://doi.org/10.1007/978-3-319-92967-5_9 |
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