The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites

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Item Type:	Review
Title:	The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites
Creators Name:	Grzybek, M., Golonko, A., Górska, A., Szczepaniak, K., Strachecka, A., Lass, A. and Lisowski, P.
Abstract:	The CRISPR/Cas9 system, a natural defence system of bacterial organisms, has recently been used to modify genomes of the most important protozoa parasites. Successful genome manipulations with the CRISPR/Cas9 system are changing the present view of genetics in parasitology. The application of this system offers a major chance to overcome the current restriction in culturing, maintaining and analysing protozoan parasites, and allows dynamic analysis of parasite genes functions, leading to a better understanding of pathogenesis. CRISPR/Cas9 system will have a significant influence on the process of developing novel drugs and treatment strategies against protozoa parasites.
Keywords:	CRISPR, Cas9, Genetic Modification, Protozoa, Apicomplexa, Genome Editing, Animals
Source:	Applied Microbiology and Biotechnology
ISSN:	0175-7598
Publisher:	Springer
Volume:	102
Number:	11
Page Range:	4629-4640
Date:	June 2018
Official Publication:	https://doi.org/10.1007/s00253-018-8927-3
PubMed:	View item in PubMed

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