Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate

Tools

Item Type:	Article
Title:	Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate
Creators Name:	Wright, D., Ferjentsik, Z., Chong, S.W., Qiu, X., Yun-Jin, J., Malapert, P., Pourquié, O., Van Hateren, N., Wilson, S.A., Franco, C., Gerhardt, H., Dale, J.K. and Maroto, M.
Abstract:	Somites are formed progressively from the presomitic mesoderm (PSM) in a highly regulated process according to a strict periodicity driven by an oscillatory mechanism. The Notch and Wnt pathways are key components in the regulation of this somitic oscillator and data from Xenopus and zebrafish embryos indicate that the Notch-downstream target Nrarp participates in the regulation of both activities. We have analyzed Nrarp/nrarp-a expression in the PSM of chick, mouse and zebrafish embryos, and we show that it cycles in synchrony with other Notch regulated cyclic genes. In the mouse its transcription is both Wnt- and Notch-dependent, whereas in the chick and fish embryo it is simply Notch-dependent. Despite oscillating mRNA levels, Nrarp protein does not oscillate in the PSM. Finally, neither gain nor loss of Nrarp function interferes with the normal expression of Notch-related cyclic genes.
Keywords:	Nrarp, Notch Pathway, Embryo, Somitic Oscillator, PSM, Cyclic Gene, Animals, Mice, Zebrafish
Source:	Developmental Dynamics
ISSN:	1058-8388
Publisher:	Wiley-Liss
Volume:	238
Number:	12
Page Range:	3043-3055
Date:	December 2009
Official Publication:	https://doi.org/10.1002/dvdy.22139
PubMed:	View item in PubMed

Repository Staff Only: item control page