The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance

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Item Type:	Article
Title:	The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance
Creators Name:	Royla, N. and Kempa, S.
Abstract:	Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3' untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.
Keywords:	Drug Resistance, Cancer Metabolism, Glutamine, Post-Transcriptional Regulation
Source:	Molecular & Cellular Oncology
ISSN:	2372-3556
Publisher:	Taylor & Francis
Volume:	4
Number:	4
Page Range:	e1338209
Date:	5 July 2017
Additional Information:	Copyright © 2017 Max Delbrück Center for Molecular Medicine
Official Publication:	https://doi.org/10.1080/23723556.2017.1338209
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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