Development of mouse model systems of germinal center lymphomas

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Item Type:	Article
Title:	Development of mouse model systems of germinal center lymphomas
Creators Name:	Kabrani, E. and Sander, S.
Abstract:	Germinal centers (GC) are the predominant origin of human B cell lymphomagenesis. Transgenic mice in which gene expression is altered specifically in GC B cells have broadened our knowledge about the mechanisms of malignant transformation. However, extensive resources are needed due to the genetic complexity of these mouse models. Thus, bone marrow (BM)-derived chimerism is an attractive approach to study GC B cell derived lymphomagenesis, as it allows for an efficient allocation of resources and reduces the number of animals used.
Keywords:	Lymphomagenesis, Mouse Model, BM Chimerism, SHM Assay, Animals, Mice
Source:	Methods in Molecular Biology
Series Name:	Methods in Molecular Biology
Title of Book:	Germinal Centers : Methods and Protocols
ISSN:	1064-3745
ISBN:	978-1-4939-7094-0
Publisher:	Springer / Humana Press
Volume:	1623
Page Range:	233-242
Date:	2017
Official Publication:	https://doi.org/10.1007/978-1-4939-7095-7_18
PubMed:	View item in PubMed

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