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| Item Type: | Article |
|---|---|
| Title: | Excitatory microcircuits within superficial layers of the medial entorhinal cortex |
| Creators Name: | Winterer, J., Maier, N., Wozny, C., Beed, P., Breustedt, J., Evangelista, R., Peng, Y., D'Albis, T., Kempter, R. and Schmitz, D. |
| Abstract: | The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on the local microcircuitry. However, local networks within the MEC are still not sufficiently characterized. Here, applying up to eight simultaneous whole-cell recordings in acute brain slices, we demonstrate the existence of unitary excitatory connections between principal neurons in the superficial layers of the MEC. In particular, we find prevalent feed-forward excitation from pyramidal neurons in layer III and layer II onto stellate cells in layer II, which might contribute to the generation or the inheritance of grid cell patterns. |
| Keywords: | Entorhinal Cortex, Excitatory Postsynaptic Potentials, Nerve Net, Pyramidal Cells, Animals, Rats, Rats, Wistar |
| Source: | Cell Reports |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press / Elsevier |
| Volume: | 19 |
| Number: | 6 |
| Page Range: | 1110-1116 |
| Date: | 9 May 2017 |
| Official Publication: | https://doi.org/10.1016/j.celrep.2017.04.041 |
| PubMed: | View item in PubMed |
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