ANGPTL8 (betatrophin) is expressed in visceral adipose tissue and relates to human hepatic steatosis in two independent clinical collectives

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Item Type:	Article
Title:	ANGPTL8 (betatrophin) is expressed in visceral adipose tissue and relates to human hepatic steatosis in two independent clinical collectives
Creators Name:	von Loeffelholz, C., Pfeiffer, A.F.H., Lock, J.F., Lieske, S., Döcke, S., Murahovschi, V., Kriebel, J., de Las Heras Gala, T., Grallert, H., Rudovich, N., Stockmann, M., Spranger, J., Jahreis, G., Bornstein, S.R., Lau, G., Xu, A., Schulz-Menger, J., Exner, L., Haufe, S., Jordan, J., Engeli, S. and Birkenfeld, A.L.
Abstract:	Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated.Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=-0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.
Keywords:	Diabetes, Fatty Acids, Insulin Resistance, Fatty Liver, Hepokine, HDL, LDL, Triacylglycerides
Source:	Hormone and Metabolic Research
ISSN:	0018-5043
Publisher:	Thieme
Volume:	49
Number:	5
Page Range:	343-349
Date:	May 2017
Official Publication:	https://doi.org/10.1055/s-0043-102950
PubMed:	View item in PubMed

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