Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies

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Item Type:	Article
Title:	Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies
Creators:	Hoeller, A., Ehrlich, L., Golic, M. ORCID: https://orcid.org/0000-0003-3030-2678, Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Perschel, F.H., Siwetz, M., Henrich, W., Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080, Huppertz, B. ORCID: https://orcid.org/0000-0003-4814-2158 and Verlohren, S. ORCID: https://orcid.org/0000-0003-3507-8636
Abstract:	Objective: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. Methods: Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Results: Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction. Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
Keywords:	sFlt-1/PlGF, sFlt-1, PlGF, Preeclampsia, Intrauterine Growth Restriction
Source:	Hypertension in Pregnancy
ISSN:	1064-1955
Publisher:	Informa Healthcare
Volume:	36
Number:	2
Page Range:	151-160
Date:	May 2017
Official Publication:	https://doi.org/10.1080/10641955.2016.1273363
PubMed:	View item in PubMed

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