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| Item Type: | Article |
|---|---|
| Title: | Astrocytic calcium waves signal brain injury to neural stem and progenitor cells |
| Creators Name: | Kraft, A., Jubal, E.R., von Laer, R., Döring, C., Rocha, A., Grebbin, M., Zenke, M., Kettenmann, H., Stroh, A. and Momma, S. |
| Abstract: | Brain injuries, such as stroke or trauma, induce neural stem cells in the subventricular zone (SVZ) to a neurogenic response. Very little is known about the molecular cues that signal tissue damage, even over large distances, to the SVZ. Based on our analysis of gene expression patterns in the SVZ, 48 hr after an ischemic lesion caused by middle cerebral artery occlusion, we hypothesized that the presence of an injury might be transmitted by an astrocytic traveling calcium wave rather than by diffusible factors or hypoxia. Using a newly established in vitro system we show that calcium waves induced in an astrocytic monolayer spread to neural stem and progenitor cells and increase their self-renewal as well as migratory behavior. These changes are due to an upregulation of the Notch signaling pathway. This introduces the concept of propagating astrocytic calcium waves transmitting brain injury signals over long distances. |
| Keywords: | Adenosine Triphosphate, Astrocytes, Brain Injuries, Calcium, Calcium Signaling, Cell Differentiation, Cell Movement, Cell Self Renewal, Cells, Cultured, Disease Models, Animal, Gap Junctions, Gene Expression Profiling, Neural Stem Cells, Time Factors, Transcriptome, Animals, Mice |
| Source: | Stem Cell Reports |
| ISSN: | 2213-6711 |
| Publisher: | Cell Press / Elsevier |
| Volume: | 8 |
| Number: | 3 |
| Page Range: | 701-714 |
| Date: | 14 March 2017 |
| Official Publication: | https://doi.org/10.1016/j.stemcr.2017.01.009 |
| PubMed: | View item in PubMed |
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