Blood flow boosts BMP signaling to keep vessels in shape

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Item Type:	Editorial
Title:	Blood flow boosts BMP signaling to keep vessels in shape
Creators Name:	Franco, C.A. and Gerhardt, H.
Abstract:	Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.
Keywords:	Biological Models, Blood Vessels, Bone Morphogenetic Proteins, Regional Blood Flow, Signal Transduction, Animals, Mice
Source:	Journal of Cell Biology
ISSN:	0021-9525
Publisher:	Rockefeller University Press
Volume:	214
Number:	7
Page Range:	793-795
Date:	26 September 2016
Official Publication:	https://doi.org/10.1083/jcb.201609038
PubMed:	View item in PubMed

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