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Blood flow boosts BMP signaling to keep vessels in shape

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Item Type:Editorial
Title:Blood flow boosts BMP signaling to keep vessels in shape
Creators Name:Franco, C.A. and Gerhardt, H.
Abstract:Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.
Keywords:Biological Models, Blood Vessels, Bone Morphogenetic Proteins, Regional Blood Flow, Signal Transduction, Animals, Mice
Source:Journal of Cell Biology
ISSN:0021-9525
Publisher:Rockefeller University Press
Volume:214
Number:7
Page Range:793-795
Date:26 September 2016
Official Publication:https://doi.org/10.1083/jcb.201609038
PubMed:View item in PubMed

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