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| Item Type: | Editorial |
|---|---|
| Title: | Blood flow boosts BMP signaling to keep vessels in shape |
| Creators Name: | Franco, C.A. and Gerhardt, H. |
| Abstract: | Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence. |
| Keywords: | Biological Models, Blood Vessels, Bone Morphogenetic Proteins, Regional Blood Flow, Signal Transduction, Animals, Mice |
| Source: | Journal of Cell Biology |
| ISSN: | 0021-9525 |
| Publisher: | Rockefeller University Press |
| Volume: | 214 |
| Number: | 7 |
| Page Range: | 793-795 |
| Date: | 26 September 2016 |
| Official Publication: | https://doi.org/10.1083/jcb.201609038 |
| PubMed: | View item in PubMed |
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