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| Item Type: | Article |
|---|---|
| Title: | Myocardial effective transverse relaxation time T(2)* correlates with left ventricular wall thickness: a 7.0 T MRI study |
| Creators Name: | Huelnhagen, T., Hezel, F., Serradas Duarte, T., Pohlmann, A., Oezerdem, C., Flemming, B., Seeliger, E., Prothmann, M., Schulz-Menger, J. and Niendorf, T. |
| Abstract: | PURPOSE: Myocardial effective relaxation time T2* is commonly regarded as a surrogate for myocardial tissue oxygenation. However, it is legitimate to assume that there are multiple factors that influence T2*. To this end, this study investigates the relationship between T2* and cardiac macromorphology given by left ventricular (LV) wall thickness and left ventricular radius, and provides interpretation of the results in the physiological context. METHODS: High spatio-temporally resolved myocardial CINE T2* mapping was performed in 10 healthy volunteers using a 7.0 Tesla (T) full-body MRI system. Ventricular septal wall thickness, left ventricular inner radius, and T2* were analyzed. Macroscopic magnetic field changes were elucidated using cardiac phase-resolved magnetic field maps. RESULTS: Ventricular septal T2* changes periodically over the cardiac cycle, increasing in systole and decreasing in diastole. Ventricular septal wall thickness and T2* showed a significant positive correlation, whereas the inner LV radius and T2* were negatively correlated. The effect of macroscopic magnetic field gradients on T2* can be considered minor in the ventricular septum. CONCLUSION: Our findings suggest that myocardial T2* is related to tissue blood volume fraction. Temporally resolved T2* mapping could be beneficial for myocardial tissue characterization and for understanding cardiac (patho)physiology in vivo. |
| Keywords: | Magnetic Resonance Imaging, Cardiac Imaging, Ultrahigh Field MR, Myocardial Tissue Characterization, Susceptibility Weighted Imaging, T2*, Myocardial Wall Thickness |
| Source: | Magnetic Resonance in Medicine |
| ISSN: | 0740-3194 |
| Publisher: | Wiley-Blackwell |
| Volume: | 77 |
| Number: | 6 |
| Page Range: | 2381-2389 |
| Date: | June 2017 |
| Official Publication: | https://doi.org/10.1002/mrm.26312 |
| PubMed: | View item in PubMed |
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