Failure of natalizumab to prevent relapses in neuromyelitis optica

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Item Type:	Article
Title:	Failure of natalizumab to prevent relapses in neuromyelitis optica
Creators Name:	Kleiter, I., Hellwig, K., Berthele, A., Kuempfel, T., Linker, R.A., Hartung, H.P., Paul, F. and Aktas, O.
Abstract:	Objective: To describe first experiences with the integrin inhibitor natalizumab, given to patients with suspected relapsing-remitting multiple sclerosis (MS) who were later diagnosed with aquaporin 4–positive neuromyelitis optica (NMO). Design: Retrospective case series. Setting: Neurology departments at tertiary referral centers in Germany. Patients: Patients with NMO who tested positive for antibodies to aquaporin 4. Intervention: Treatment with natalizumab. Main Outcome Measures: Relapses and accumulation of disability. Results: We identified 5 patients (4 female; median age, 45 years) who were initially diagnosed with MS and treated with natalizumab before diagnosis of NMO was established. Natalizumab was given as escalation therapy after failure of first- or second-line immunomodulatory therapies for MS. During natalizumab therapy (median duration, 8 infusions; range, 2-11 infusions), all 5 patients displayed persisting disease activity; a total of 9 relapses occurred (median duration to relapse, 120 days; range, 45-230 days) after the start of treatment. Four patients had an accumulation of disability and 1 patient died 2 months after cessation of natalizumab treatment. Conclusions: Our results suggest that natalizumab fails to control disease activity in patients with NMO. Neuromyelitis optica should be considered as a differential diagnosis in patients with suspected MS who are unresponsive to natalizumab therapy.
Keywords:	Aquaporin 4, Autoantibodies, Disability Evaluation, Humanized Monoclonal Antibodies, Natalizumab, Neuromyelitis Optica, Relapsing-Remitting Multiple Sclerosis, Secondary Prevention, Treatment Failure, Treatment Outcome
Source:	Archives of Neurology
ISSN:	0003-9942
Volume:	69
Number:	2
Page Range:	239-245
Date:	February 2012
Official Publication:	https://doi.org/10.1001/archneurol.2011.216
PubMed:	View item in PubMed

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