Visual evoked potentials in neuromyelitis optica and its spectrum disorders

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Item Type:	Article
Title:	Visual evoked potentials in neuromyelitis optica and its spectrum disorders
Creators Name:	Ringelstein, M., Kleiter, I., Ayzenberg, I., Borisow, N., Paul, F., Ruprecht, K., Kraemer, M., Cohn, E., Wildemann, B., Jarius, S., Hartung, H.P., Aktas, O. and Albrecht, P.
Abstract:	Optic neuritis (ON) is a key feature of neuromyelitis optica (NMO). Recently, NMO patients of predominantly Afro-Brazilian origin were evaluated by visual evoked potentials (VEPs) and showed marked amplitude reductions. Here, we analyzed VEPs in a predominantly Caucasian cohort, consisting of 43 patients with definite NMO, 18 with anti-aquaporin (AQP) 4 antibody-seropositive NMO spectrum disorders and 61 matched healthy controls. We found reduced amplitudes in only 12.3%, prolonged latencies in 41.9% and a lack of response in 14.0% of NMO eyes. Delayed P100 latencies in eyes without prior ON suggested this was a subclinical affection. The data indicate heterogenous patterns in NMO, warranting further investigation.
Keywords:	Aquaporin-4 Antibody, P100 Latency, Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorders, Optic Neuritis, Visual Evoked Potential
Source:	Multiple Sclerosis Journal
ISSN:	1352-4585
Publisher:	Sage Publications
Volume:	20
Number:	5
Page Range:	617-620
Date:	April 2014
Official Publication:	https://doi.org/10.1177/1352458513503053
PubMed:	View item in PubMed

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