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| Item Type: | Article |
|---|---|
| Title: | Prospective, randomized comparison of gadopentetate and gadobutrol to assess chronic myocardial infarction applying cardiovascular magnetic resonance |
| Creators Name: | Rudolph, A., Messroghli, D., von Knobelsdorff-Brenkenhoff, F., Traber, J., Schüler, J., Wassmuth, R. and Schulz-Menger, J. |
| Abstract: | BACKGROUND: We hypothesized that the contrast medium gadobutrol is not inferior compared to Gd-DTPA in identifying and quantifying ischemic late gadolinium enhancement (LGE), even by using a lower dose. METHODS: We prospectively enrolled 30 patients with chronic myocardial infarction as visualized by LGE during clinical routine scan at 1.5 T with 0.20 mmol/kg Gd-DTPA. Participants were randomized to either 0.15 mmol/kg gadobutrol (group A) or 0.10 mmol/kg gadobutrol (group B). CMR protocol was identical in both exams. LGE was quantified using a semiautomatic approach. Signal intensities of scar, remote myocardium, blood and air were measured. Signal to noise (SNR) and contrast to noise ratios (CNR) were calculated. RESULTS: Signal intensities were not different between Gd-DTPA and gadobutrol in group A, whereas significant differences were detected in group B. SNR of injured myocardium (53.5+/-21.4 vs. 30.1+/-10.4, p = 0.0001) and CNR between injured and remote myocardium (50.3+/-20.3 vs. 27.3+/-9.3, p < 0.0001) were lower in gadobutrol. Infarct size was lower in both gadobutrol groups compared to Gd-DTPA (group A: 16.8+/-10.2 g vs. 12.8+/-6.8 g, p = 0.03; group B: 18.6+/-12.0 g vs. 14.0+/-9.9 g, p = 0.0016). CONCLUSIONS: Taking application of 0.2 mmol/kg Gd-DTPA as the reference, the delineation of infarct scar was similar with 0.15 mmol/kg gadobutrol, whereas the use 0.10 mmol/kg gadobutrol led to reduced tissue contrast. TRIAL REGISTRATION: The study had been registered under EudraCT Number: 2010-020775-22 . Registration date: 2010.08.10. |
| Keywords: | Cardiovascular Magnetic Resonance, Contrast Media, Gadobutrol, Gd-DTPA, Chronic Myocardial Infarction, Late Gadolinium Enhancement |
| Source: | BMC Medical Imaging |
| ISSN: | 1471-2342 |
| Publisher: | BioMed Central |
| Volume: | 15 |
| Number: | 1 |
| Page Range: | 55 |
| Date: | 17 November 2015 |
| Official Publication: | https://doi.org/10.1186/s12880-015-0099-3 |
| PubMed: | View item in PubMed |
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