Validation of the Erlangen score algorithm for the prediction of the development of dementia due to Alzheimer's disease in pre-dementia subjects

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Item Type:	Article
Title:	Validation of the Erlangen score algorithm for the prediction of the development of dementia due to Alzheimer's disease in pre-dementia subjects
Creators Name:	Lewczuk, P., Kornhuber, J., Toledo, J.B., Trojanowski, J.Q., Knapik-Czajka, M., Peters, O., Wiltfang, J. and Shaw, L.M.
Abstract:	Background: In previous studies, a dichotomous stratification of subjects into "cerebrospinal fluid (CSF) normal" and "CSF pathologic" was used to investigate the role of biomarkers in the prediction of progression to dementia in pre-dementia/mild cognitive impairment subjects. With the previously published Erlangen Score Algorithm, we suggested a division of CSF patterns into five groups, covering all possible CSF result combinations based on the presence of pathologic tau and/or amyloid-{beta} CSF values. Objective: This study aimed to validate the Erlangen Score diagnostic algorithm based on the results of biomarkers analyses obtained in different patients cohorts, with different pre-analytical protocols, and with different laboratory analytical platforms. Methods: We evaluated the algorithm in two cohorts of pre-dementia subjects: the US-Alzheimer's Disease Neuroimaging Initiative and the German Dementia Competence Network. Results: In both cohorts, the Erlangen scores were strongly associated with progression to Alzheimer's disease. Neither the scores of the progressors nor the scores of the non-progressors differed significantly between the two projects, in spite of significant differences in the cohorts, laboratory methods, and the samples treatment. Conclusions: Our findings confirm the utility of the Erlangen Score algorithm as a useful tool in the early neurochemical diagnosis of Alzheimer's disease.
Keywords:	Alzheimer's Disease, Biomarkers, Cerebrospinal Fluid, Clinical Neurochemistry, Results Interpretation, Validation
Source:	Journal of Alzheimer's Disease
ISSN:	1387-2877
Publisher:	IOS Press
Volume:	48
Number:	2
Page Range:	433-441
Date:	9 September 2015
Additional Information:	Erratum in: J Alzheimers Dis 49(3): 887. - Copyright © 2015 IOS Press and the authors. All rights reserved.
Official Publication:	https://doi.org/10.3233/JAD-150342
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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