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| Item Type: | Article |
|---|---|
| Title: | Intake of meat mutagens and risk of prostate cancer in a cohort of U.S. health professionals |
| Creators Name: | Rohrmann, S., Nimptsch, K., Sinha, R., Willett, W.C., Giovannucci, E.L., Platz, E.A. and Wu, K. |
| Abstract: | BACKGROUND: Evidence relating heterocyclic aromatic amines (HCA), associated with high-temperature cooking methods, to prostate cancer risk is inconsistent Methods: In a large US cohort study, intakes of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and a meat-derived mutagenicity index (MDM) were assessed using a cooking method questionnaire administered in 1996. Until 2010, 2,770 prostate cancer cases were observed among 26,030 participants. RESULTS: Intake of PhIP from red meat was statistically significantly associated with total prostate cancer risk (top vs. bottom quintile HR=1.18, 95% CI 1.03-1.35), but not other HCAs (MeIQx, 1.12, 0.98-1.27, PhIP from white meat, 1.07, 0.94-1.21, DiMeIQx, 1.09, 0.97-1.21) or MDM (1.13, 1.00-1.28). For high grade (Gleason sum 7 with pattern 4+3 and Gleason sum 8-10, n=483 cases) and advanced cancers (n=281), we only observed positive associations for PhIP from red meat (top vs. bottom quintile: high grade: HR=1.44, 95% CI 1.04-1.98, p-trend=0.03; advanced: HR=1.50, 95% 0.99-2.26; p-trend=0.12), but associations for advanced cancers did not reach statistical significance. Observed associations remained similar after adjustment for total, unprocessed or processed red meat intake. CONCLUSION: Observed positive associations between PhIP intake from red meat and prostate cancer, particularly high-grade and possibly also advanced prostate cancer need to be confirmed in other studies. IMPACT: Results do not provide strong evidence that HCAs increase risk of prostate cancers. |
| Keywords: | Benzimidazoles, Cooking, Feeding Behavior, Follow-Up Studies, Health Personnel, Imidazoles, Incidence, Meat, Mutagens, Prostatic Neoplasms, Quinoxalines, Reproducibility of Results, Retrospective Studies, Risk Assessment, Risk Factors, Surveys and Questionnaires, United States |
| Source: | Cancer Epidemiology, Biomarkers & Prevention |
| ISSN: | 1055-9965 |
| Publisher: | American Association for Cancer Research |
| Volume: | 24 |
| Number: | 10 |
| Page Range: | 1557-1563 |
| Date: | October 2015 |
| Official Publication: | https://doi.org/10.1158/1055-9965.EPI-15-0068-T |
| PubMed: | View item in PubMed |
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