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| Item Type: | Article |
|---|---|
| Title: | Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin |
| Creators Name: | Kronenberg, G., Mosienko, V., Gertz, K., Alenina, N., Hellweg, R. and Klempin, F. |
| Abstract: | The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT(-/-) mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT(-/-) mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression. |
| Keywords: | BDNF, SERT, TPH2, Serotonin, Depression, Antidepressant, Animals, Mice |
| Source: | European Archives of Psychiatry and Clinical Neuroscience |
| ISSN: | 0940-1334 |
| Publisher: | Springer |
| Volume: | 266 |
| Number: | 3 |
| Page Range: | 281-284 |
| Date: | April 2016 |
| Official Publication: | https://doi.org/10.1007/s00406-015-0611-3 |
| PubMed: | View item in PubMed |
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