![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
| Item Type: | Review |
|---|---|
| Title: | Regulation of vascular tone and arterial blood pressure: role of chloride transport in vascular smooth muscle |
| Creators Name: | Huebner, C.A., Schroeder, B.C. and Ehmke, H. |
| Abstract: | Recent studies suggest that primary changes in vascular resistance can cause sustained changes in arterial blood pressure. In this review, we summarize current knowledge about Cl(-) homeostasis in vascular smooth muscle cells. Within vascular smooth muscle cells, Cl(-) is accumulated above the electrochemical equilibrium, causing Cl(-) efflux, membrane depolarization, and increased contractile force when Cl(-) channels are opened. At least two different transport mechanisms contribute to raise [Cl(-)] i in vascular smooth muscle cells, anion exchange, and cation-chloride cotransport. Recent work suggests that TMEM16A-associated Ca(2+)-activated Cl(-) currents mediate Cl(-) efflux in vascular smooth muscle cells leading to vasoconstriction. Additional proteins associated with Cl(-) flux in vascular smooth muscle are bestrophins, which modulate vasomotion, the volume-activated LRRC8, and the cystic fibrosis transmembrane conductance regulator (CFTR). Cl(-) transporters and Cl(-) channels in vascular smooth muscle cells (VSMCs) significantly contribute to the physiological regulation of vascular tone and arterial blood pressure. |
| Keywords: | Blood Pressure, Chloride Channel, Hypertension, Kidney, Vascular Resistance, Vasoconstriction, Animals |
| Source: | Pfluegers Archiv European Journal of Physiology |
| ISSN: | 0031-6768 |
| Publisher: | Springer |
| Volume: | 467 |
| Number: | 3 |
| Page Range: | 605-614 |
| Date: | 16 January 2015 |
| Official Publication: | https://doi.org/10.1007/s00424-014-1684-y |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
