Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis

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Item Type:	Review
Title:	Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis
Creators Name:	Mosienko, V., Beis, D., Pasqualetti, M., Waider, J., Matthes, S., Qadri, F., Bader, M. and Alenina, N.
Abstract:	Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT), a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the central nervous system. In 2003 we have discovered the existence of a second Tph gene, which is expressed exclusively in the brain, and, therefore, is responsible for the 5-HT synthesis in the central nervous system. In the following years several research groups have independently generated Tph2-deficient mice. In this review we will summarize the data gained from the existing mouse models with constitutive or conditional deletion of the Tph2 gene, focusing on biochemical, developmental, and behavioral consequences of Tph2-deficiency.
Keywords:	Serotonin, Tryptophan Hydroxylase 2, Animal Model, Behavior, Serotonin Transporter, Serotonin Receptors, Animals
Source:	Behavioural Brain Research
ISSN:	0166-4328
Publisher:	Elsevier
Volume:	277
Number:	SI
Page Range:	78-88
Date:	15 January 2015
Official Publication:	https://doi.org/10.1016/j.bbr.2014.06.005
PubMed:	View item in PubMed

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