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Multiple sclerosis: The elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1

Item Type:Article
Title:Multiple sclerosis: The elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1
Creators Name:Ruprecht, K., Wunderlich, B., Gieß, R., Meyer, P., Loebel, M., Lenz, K., Hofmann, J., Rosche, B., Wengert, O., Paul, F., Reimer, U. and Scheibenbogen, C.
Abstract:Patients with multiple sclerosis (MS) have elevated antibodies against Epstein-Barr virus (EBV), but data on the epitope-resolved specificity of these antibodies are scarce. Using a peptide microarray containing 1465 peptides representing 8 full-length EBV proteins, we identified higher (p<0.001) antibody reactivities to 39 EBV-peptides in MS patients (n=29) compared to healthy controls (n=22). Seventeen of the 39 peptides were from EBNA-1 and 13 located within the glycine-alanine repeat of EBNA-1. Further reactivities were directed against EBNA-3, EBNA-4, EBNA-6, VP26, and LMP1. Thus, antibodies against EBV in MS patients primarily target, but are not confined to, the glycine-alanine repeat of EBNA-1.
Keywords:Multiple Sclerosis, Epstein-Barr Virus, Epstein-Barr Nuclear Antigen-1, Glycine-Alanine Repea, Antibodies, Peptide Array
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier
Volume:272
Number:1-2
Page Range:56-61
Date:15 July 2014
Official Publication:https://doi.org/10.1016/j.jneuroim.2014.04.005
PubMed:View item in PubMed

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