Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

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Item Type:	Comment
Title:	Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4
Creators Name:	Sadlack, B., Kühn, R., Schorle, H., Rajewsky, K., Müller, W. and Horak, I.
Abstract:	Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2 and IL-4-deficient homozygous mice.
Keywords:	Interleukin-2, Interleukin-4, Development and Proliferation of Lymphocytes, Cytokines, Animals, Knock-Out Mice, Mice
Source:	European Journal of Immunology
ISSN:	0014-2980
Publisher:	Wiley
Volume:	24
Number:	1
Page Range:	281-284
Date:	January 1994
Official Publication:	https://doi.org/10.1002/eji.1830240144
PubMed:	View item in PubMed

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