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| Item Type: | Review |
|---|---|
| Title: | Macrophages in homeostatic immune function |
| Creators Name: | Jantsch, J., Binger, K.J., Müller, D.N. and Titze, J. |
| Abstract: | Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism as well as salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders. |
| Keywords: | Macrophage Polarization, Arteriogenesis, Angiogenesis, Lipid Metabolism, Peroxisome Proliferator Activator Receptor (PPAR), Salt, Na+ Storage, Tonicity Enhance Binding Protein (TonEBP)/Nuclear Factor of Activated T-Cells 5(NFAT5) |
| Source: | Frontiers in Physiology |
| ISSN: | 1664-042X |
| Publisher: | Frontiers Media SA |
| Volume: | 5 |
| Page Range: | 146 |
| Date: | May 2014 |
| Additional Information: | This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. |
| Official Publication: | https://doi.org/10.3389/fphys.2014.00146 |
| PubMed: | View item in PubMed |
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