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| Item Type: | Article |
|---|---|
| Title: | Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease |
| Creators Name: | Wittenbecher, F., Rieger, K., Dziubianau, M., Herholz, A., Mensen, A., Blau, I.W., Uharek, L., Dörken, B., Thiel, A. and Na, I.K. |
| Abstract: | Rabbit antithymocyte globulin (Thymoglobulin(®)) is commonly used as graft-versus-host disease (GvHD) prophylaxis. Since we found similar total CD8 T cell numbers in patients with and without Thymoglobulin(®) therapy within the first six months after allogeneic hematopoietic stem cell transplantation, we have analyzed the reconstitution of the CD8 T cell compartment in detail. After T cell-depletion, higher and more sustained proliferative capacity of memory CD8 T cells resulted in their rapid expansion, whereas the fraction of naive CD8 T cells decreased. Importantly, this shift towards effector memory CD8 T cells did not accelerate the incidence of GvHD. |
| Keywords: | HSCT, Antithymocyte Globulin, CD8 T Cell, Effector Memory, Naive |
| Source: | Leukemia Research Reports |
| ISSN: | 2213-0489 |
| Publisher: | Elsevier |
| Volume: | 2 |
| Number: | 2 |
| Page Range: | 82-85 |
| Date: | 27 September 2013 |
| Official Publication: | https://doi.org/10.1016/j.lrr.2013.09.001 |
| PubMed: | View item in PubMed |
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