![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
| Item Type: | Article |
|---|---|
| Title: | Simultaneous dual contrast weighting using double echo rapid acquisition with relaxation enhancement (RARE) imaging |
| Creators Name: | Fuchs, K., Hezel, F., Klix, S., Mekle, R., Wuerfel, J. and Niendorf, T. |
| Abstract: | PURPOSE: This work proposes a dual contrast rapid acquisition with relaxation enhancement (RARE) variant (2in1-RARE), which provides simultaneous proton density (PD) and T2 * contrast in a single acquisition. THEORY AND METHODS: The underlying concept of 2in1-RARE is the strict separation of spin echoes and stimulated echoes. This approach offers independent weighting of spin echoes and stimulated echoes. 2in1-RARE was evaluated in phantoms including signal-to-noise ratio (SNR) and point spread function assessment. 2in1-RARE was benchmarked versus coherent RARE and a split-echo RARE variant. The applicability of 2in1-RARE for brain imaging was demonstrated in a small cohort of healthy subjects (n = 10) and, exemplary, a multiple sclerosis patient at 3 Tesla as a precursor to a broader clinical study. RESULTS: 2in1-RARE enables the simultaneous acquisition of dual contrast weighted images without any significant image degradation and without sacrificing SNR versus split-echo RARE. This translates into a factor of two speed gain over multi-contrast, sequential split-echo RARE. A 15% broadening of the point spread function was observed in 2in1-RARE. T1 relaxation effects during the mixing time can be neglected for brain tissue. CONCLUSION: 2in1-RARE offers simultaneous acquisition of images of anatomical (PD) and functional (T2 *) contrast. It presents an alternative to address scan time constraints frequently encountered during sequential acquisition of T2 * or PD-weighted RARE. |
| Keywords: | Magnetic Resonance Imaging, Spin Echo, Stimulated Echo, Fast Imaging, Susceptibility, Dual Contrast |
| Source: | Magnetic Resonance in Medicine |
| ISSN: | 0740-3194 |
| Publisher: | Wiley-Blackwell |
| Volume: | 72 |
| Number: | 6 |
| Page Range: | 1590-1598 |
| Date: | December 2014 |
| Official Publication: | https://doi.org/10.1002/mrm.25066 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
