Effects of tamoxifen, droloxifene and 17beta-estradiol on Rauscher mouse leukemogenesis

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Item Type:	Article
Title:	Effects of tamoxifen, droloxifene and 17beta-estradiol on Rauscher mouse leukemogenesis
Creators Name:	Sydow, G. and Wunderlich, V.
Abstract:	The effects of tamoxifen (TAM), its 3-hydroxy congener droloxifene (DROL) and 17 beta-estradiol were investigated on leukemogenesis induced in BALB/c mice by Rauscher murine leukemia virus (RLV). Multiple applications of each compound, in a dose-dependent manner, resulted in reduced virus titer in the serum, delayed onset of splenomegaly and significant prolongation of survival. Although 17 beta-estradiol proved most effective, prevention of disease was not achieved either by short- or long-term treatment with any of the drugs tested.
Keywords:	Tamoxifen, Droloxifene, 17{beta}-Estradiol, Leukemogenesis, Retroviruses, Rauscher Murine Leukemia, Animals, Mice
Source:	Cancer Letters
ISSN:	0304-3835
Publisher:	Elsevier
Volume:	82
Number:	1
Page Range:	89-94
Date:	15 July 1994
Official Publication:	https://doi.org/10.1016/0304-3835(94)90150-3
PubMed:	View item in PubMed

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