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Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats

Item Type:Article
Title:Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats
Creators Name:Stief, F., Piechotta, A., Gabriel, S., Schmitz, D. and Draguhn, A.
Abstract:Inhibitory postsynaptic currents were measured in CA1 pyramidal cells from chronically epileptic rats (pilocarpine model). Tiagabine, a selective inhibitor of the GABA-uptake transporter 1 prolonged currents equally to cells from control animals. Thus, GABA-uptake has an unaltered impact on inhibitory synaptic efficacy in rats with chronic temporal lobe epilepsy, underlining the rational for the use of GABA-uptake blockers in this condition.
Keywords:Inhibitory Postsynaptic Currents, GABA Uptake, Pilocarpine, Epilepsy, Tiagabine, Animals, Rats
Source:Epilepsy Research
ISSN:0920-1211
Publisher:Elsevier
Volume:66
Number:1-3
Page Range:199-202
Date:August 2005
Official Publication:https://doi.org/10.1016/j.eplepsyres.2005.07.006
PubMed:View item in PubMed

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