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| Item Type: | Article |
|---|---|
| Title: | Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions |
| Creators Name: | Schäfer, G., Milić, J, Eldahshan, A, Götz, F., Zühlke, K., Schillinger, C., Kreuchwig, A., Elkins, J.M., Abdul Azeez, K.R.A., Oder, A., Moutty, M.C., Masada, N., Beerbaum, M., Schlegel, B., Niquet, S., Schmieder, P., Krause, G., von Kries, J.P., Cooper, D.M.F., Knapp, S., Rademann, J., Rosenthal, W. and Klussmann, E. |
| Abstract: | A good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinase A (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α-helix mimetics for the inhibition of such interactions and are the first biologically active, nonpeptidic compounds that block the AKAP binding site of PKA. |
| Keywords: | AKAP, Peptide Mimetics, Protein Kinase A, Protein-Protein Interactions, Suzuki Coupling, Terpyridines |
| Source: | Angewandte Chemie International Edition |
| ISSN: | 1433-7851 |
| Publisher: | Wiley |
| Volume: | 52 |
| Number: | 46 |
| Page Range: | 12187-12191 |
| Date: | 11 November 2013 |
| Official Publication: | https://doi.org/10.1002/anie.201304686 |
| PubMed: | View item in PubMed |
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