Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study

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Item Type:	Article
Title:	Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study
Creators Name:	Sinn, M., Striefler, J.K., Sinn, B.V., Sallmon, D., Bischoff, S., Stieler, J.M., Pelzer, U., Bahra, M., Neuhaus, P., Doerken, B., Denkert, C., Riess, H. and Oettle, H.
Abstract:	BACKGROUND: Long-term survival (LTS) in patients (pts) with pancreatic cancer is still uncommon, little data is available to identify long-term survivors. The CONKO-001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question. METHODS: CONKO-001 pts with an overall survival >/=5 years were compared to those who survived <5 years. Central re-evaluation of primary histology was performed. Univariate analysis with the chi(2) -test identified qualifying factors. Logistic regression was used to investigate the influence of these covariates on LTS. RESULTS: Of the evaluable 354 CONKO-001 pts, 54 (15%) with an overall survival >/=5 years were identified. It was possible to obtain tumor specimens of 39 pts (72%). Histological re-evaluation confirmed adenocarcinoma in 38 pts, 1 showed a high-grade neuroendocrine tumor. Univariate analysis for all 53 LTS pts with adenocarcinoma compared to the remaining 300 non-LTS pts revealed as relevant active treatment, tumor grading, tumor size, lymph nodes. No significance could be demonstrated for resection margin, sex, age, Karnofsky performance status, CA 19-9 at study entry. In multivariate analysis, tumor grading, active treatment, tumor size, lymph node involvement were independent prognostic factors for LTS. CONCLUSION: Long-term survival can be achieved in adenocarcinoma of the pancreas.
Keywords:	Rate of Cure, Adjuvant Therapy, Gemcitabine
Source:	Journal of Surgical Oncology
ISSN:	0022-4790
Publisher:	Wiley-Blackwell
Volume:	108
Number:	6
Page Range:	398-402
Date:	November 2013
Official Publication:	https://doi.org/10.1002/jso.23409
PubMed:	View item in PubMed

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