Impact of beta-amyloid-specific florbetaben PET imaging on confidence in early diagnosis of Alzheimer's disease

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Item Type:	Article
Title:	Impact of beta-amyloid-specific florbetaben PET imaging on confidence in early diagnosis of Alzheimer's disease
Creators Name:	Schipke, C.G., Peters, O., Heuser, I., Grimmer, T., Sabbagh, M.N., Sabri, O., Hock, C., Kunz, M., Kuhlmann, J., Reininger, C. and Blankenburg, M.
Abstract:	Background: Early diagnosis of Alzheimer's disease (AD) may be corroborated by imaging of beta-amyloid plaques using positron emission tomography (PET). Here, we performed an add-on questionnaire study to evaluate the relevance of florbetaben imaging (BAY 949172) in diagnosis and consecutive management of probable AD patients. Methods: AD patients with a clinical diagnosis in accordance with the NINCDS-ADRDA criteria or controls were imaged using florbetaben. Referring physicians were asked on a voluntary basis about their confidence in initial diagnosis, significance of PET imaging results, and their anticipated consequences for future patient care. Results: 121 questionnaires for probable AD patients and 80 questionnaires for controls were evaluated. In 18% of patients who had initially received the diagnosis of probable AD, PET scans were rated negative, whereas in controls 18% of scans were positive. An increase in confidence in the initial diagnosis was frequently reported (80%). Imaging results had a significant impact on the intended patient care, as judged by the referring physicians; this was most prominent in those patients with a contradicting scan and/or a low confidence in the initial diagnosis. Conclusion: Florbetaben amyloid imaging increases the overall confidence in diagnosis of AD and may frequently influence clinical decisions and patient management.
Keywords:	Alzheimer’s Disease, Beta-Amyloid Plaques, Florbetaben, Amyloid Imaging
Source:	Dementia and Geriatric Cognitive Disorders
ISSN:	1420-8008
Publisher:	Karger
Volume:	33
Number:	6
Page Range:	416-422
Date:	August 2012
Additional Information:	Erratum in: Dement Geriatr Cogn Disord 33(6): 416-422.
Official Publication:	https://doi.org/10.1159/000339367
PubMed:	View item in PubMed

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