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Are agonistic autoantibodies against G-protein coupled receptors involved in the development of long-term side effects of tumor chemotherapy?

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Item Type:Article
Title:Are agonistic autoantibodies against G-protein coupled receptors involved in the development of long-term side effects of tumor chemotherapy?
Creators Name:Haberland, A., Santos, R.A.S., Schimke, I. and Wallukat, G.
Abstract:Metabolic syndrome and cardiomyopathies are long-term consequences of chemo- and radiotherapy and develop long after completing the initial tumor treatment. The slow progression of such late effects might be an indication of the involvement of autoimmune processes in the development of such follow-up consequences. Functionally active autoantibodies, which permanently stimulate relevant cell receptors, might be a crucial component. Here, we report the detection of functionally active agonistic autoantibodies such as the autoantibody against the adrenergic alpha1-receptor, the muscarinic M2-receptor, and the newly discovered autoantibody against the Mas-receptor in the plasma of a cancer survivor following chemotherapy treatment.
Keywords:Agonistic Autoantibodies, G-Protein Coupled Receptor Autoantibodies, Chemotherapy, Tumor Therapy, Cardiomyopathy, Metabolic Syndrome, Long-Term Disturbances
Source:Case Reports in Oncology
ISSN:1662-6575
Publisher:Karger
Volume:6
Number:1
Page Range:104-108
Date:January 2013
Official Publication:https://doi.org/10.1159/000348425
PubMed:View item in PubMed

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