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| Item Type: | Article |
|---|---|
| Title: | ANCA-assoziierte Vaskulitiden: Neuere Aspekte der Entstehung [Antineutrophil cytoplasmic antibody-associated vasculitis: novel aspects in the pathogenesis] |
| Creators Name: | Schreiber, A., Choi, M. and Kettritz, R. |
| Abstract: | Antineutrophil cytoplasmic antibodies (ANCA) occur in patients with small vessel vasculitis and necrotizing crescentic glomerulonephritis. The main target antigens are proteinase 3 (PR3) and myeloperoxidase (MPO). Novel findings implicate lysosomal-associated membrane protein 2 (LAMP-2) as an additional antigen and epigenetic mechanisms as important transcriptional regulators for PR3 and MPO expression. Generation of ANCAs is a consequence of a complex interplay between antigen presentation, T-cells and B-cells. Recent data underline the significance of distinct CD4+T-cell subsets. A complementary PR3 protein has been identified which not only triggers the generation of anti-idiotypic antibodies recognizing PR3 but also constituents of the coagulation cascade. Additional important ANCA-induced neutrophil and monocyte effector functions were identified, such as the formation of DNA-containing neutrophil extracellular traps (NETs), the activation of a specific phosphatidylinositol-3 kinase isoform and the neutrophil serine protease-dependent IL-1{beta} generation. Animal models allow testing of treatment strategies which target these new molecules. |
| Keywords: | Vasculitis, Antineutrophil Cytoplasmic Antibodies, Pathogenesis, Leukocytes, Animal Models, Animals, Mice |
| Source: | Nephrologe |
| ISSN: | 1862-040X |
| Publisher: | Springer |
| Volume: | 7 |
| Number: | 3 |
| Page Range: | 192-199 |
| Date: | May 2012 |
| Official Publication: | https://doi.org/10.1007/s11560-011-0606-7 |
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