Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo

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Item Type:	Article
Title:	Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo
Creators Name:	Mueller, K., von Maessenhausen, A., Aichele, U., Staerck, L., Leisegang, M., Uckert, W. and Pircher, H.
Abstract:	The transfer of TCR genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
Keywords:	Antigens, CD8-Positive T-Lymphocytes, Cell Membrane, Cytokines, Flow Cytometry, Glycoproteins, Interferon-gamma, Listeria monocytogenes, Lymphocytes, Lymphocytic choriomeningitis virus, Peptide Fragments, Phenotype, Retroviridae, Spleen, T-Cell Antigen Receptors, Viral Antigens, Viral Proteins, Animals, Mice
Source:	Journal of Virology
ISSN:	0022-538X
Publisher:	American Society for Microbiology
Volume:	86
Number:	19
Page Range:	10866-10869
Date:	October 2012
Official Publication:	https://doi.org/10.1128/JVI.01472-12
PubMed:	View item in PubMed

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