23Na magnetic resonance imaging of tissue sodium

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Item Type:	Article
Title:	23Na magnetic resonance imaging of tissue sodium
Creators Name:	Kopp, C., Linz, P., Wachsmuth, L., Dahlmann, A., Horbach, T., Schoefl, C., Renz, W., Santoro, D., Niendorf, T., Mueller, D.N., Neininger, M., Cavallaro, A., Eckardt, K.U., Schmieder, R.E., Luft, F.C., Uder, M. and Titze, J.
Abstract:	Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body is difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals and 3T for humans to quantify Na(+) content in skeletal muscle and skin. We compared (23)Na-MRI data with actual tissue Na(+) content measured by chemical analysis in animal and human tissue. We then quantified tissue Na(+) content in normal humans and in patients with primary aldosteronism. We found a 29% increase in muscle Na(+) content in patients with aldosteronism compared with normal women and men. This tissue Na(+) was mobilized after successful treatment without accompanying weight loss. We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na(+) accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible.
Keywords:	Aldosterone, MRI, Sodium, Hypertension, Animals, Mice, Rats
Source:	Hypertension
ISSN:	0194-911X
Publisher:	American Heart Association
Volume:	59
Number:	1
Page Range:	167-172
Date:	January 2012
Official Publication:	https://doi.org/10.1161/HYPERTENSIONAHA.111.183517
PubMed:	View item in PubMed

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