Discovery of a novel tumour metastasis-promoting gene, NVM-1

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Item Type:	Article
Title:	Discovery of a novel tumour metastasis-promoting gene, NVM-1
Creators Name:	Thiele, W., Novac, N., Mink, S., Schreiber, C., Plaumann, D., Fritzmann, J., Cremers, N., Rothley, M., Schwager, C., Regiert, T., Huber, P.E., Stein, U., Schlag, P., Moll, J., Abdollahi, A. and Sleeman, J.P.
Abstract:	We have previously reported that over-expression of a panel of 119 genes correlates with the metastatic potential of pancreatic carcinoma cells. We sought to identify and functionally characterize candidate tumour metastasis promoting genes among this library using a secondary phenotype-assisted screen. Here we report the discovery of the metastasis-promoting function of a hitherto not characterized gene located on chromosome 14 (ORF138), which we have named 'novel metastasis-promoting gene 1' (NVM-1). The NVM-1 transcript is extensively alternatively spliced, is expressed endogenously in a number of different tissues, and is strongly over-expressed at the protein level in a variety of human tumour types. Importantly, NVM-1 expression stimulates the migratory and invasive behaviour of tumour cells and promotes metastasis formation in experimental animals in vivo. Up-regulation of FMNL2 and MT1E and down-regulation of TIMP4 and MHC-I is observed as a consequence of NVM-1 expression. Together these data identify NVM-1 as a gene that is functionally involved in tumour metastasis, and suggest that NVM-1 may constitute a promising therapeutic target for inhibition of tumour metastasis.
Keywords:	Tumour, Metastasis, Motility, Dissemination, Invasion, Animals, Mice
Source:	Journal of Pathology
ISSN:	0022-3417
Publisher:	Wiley-Blackwell
Volume:	225
Number:	1
Page Range:	96-105
Date:	September 2011
Official Publication:	https://doi.org/10.1002/path.2924
PubMed:	View item in PubMed

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