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| Item Type: | Article |
|---|---|
| Title: | Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels |
| Creators Name: | Fisher, E., Schulze, M.B., Stefan, N., Haering, H.U., Doering, F., Joost, H.G., Al-Hasani, H., Boeing, H. and Pischon, T. |
| Abstract: | Adipose tissue is a key factor determining C-reactive protein (CRP) plasma levels. Variation at the fat-mass and obesity-associated (FTO) gene locus has been reported to be associated with increased body fat. We investigated whether the FTO rs9939609 T>A single nucleotide polymorphism might alter CRP levels in a population-based sample of 2,415 participants from a large prospective cohort study. Genotype/phenotype relationships were studied by linear trend analysis stratified by sex. The rs9939609 A-allele was significantly associated with CRP levels in both genders (men, +21%, P = 0.002; women, +14%, P = 0.01 per A-allele). The association was attenuated, but remained statistically significant after additional adjustment for BMI, waist-to-hip ratio, and other potential confounding factors (men, +14%, P = 0.03; women, +12%, P = 0.02; per A-allele). Similar results were obtained when subjects with CRP levels higher then 10 mg/l were excluded. Our data provide preliminary evidence that the FTO rs9939609 T>A polymorphism contributes to variation in plasma CRP levels independently of obesity indices. |
| Keywords: | Alleles, C-Reactive Protein, Cohort Studies, Genotype, Linear Models, Obesity, Single Nucleotide Polymorphism, Prospective Studies, Proteins |
| Source: | Obesity |
| ISSN: | 1930-7381 |
| Publisher: | NAASO The Obesity Society |
| Volume: | 17 |
| Number: | 2 |
| Page Range: | 330-334 |
| Date: | February 2009 |
| Official Publication: | https://doi.org/10.1038/oby.2008.465 |
| PubMed: | View item in PubMed |
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